Executive summary

This study by Mayo Clinic aimed to compare Functional Assessment of Cancer Therapy - Esophagus (FACT-E) questionnaire changes during proton (PRT) or photon (XRT) chemoradiotherapy (CRT) for esophageal cancer (EC). 125 patients completed a baseline and post-treatment FACT-E; 63 received XRT and 62 received PRT.

This study found that less mean decline in FACT-E score was observed for PRT vs XRT (-12.7 vs -20.6, p=0.026). The authors concluded that for patients receiving CRT for EC, PRT was associated with less decline in FACT-E scores compared to XRT.

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