Subtitle
Hypofractionated proton beam therapy for centrally located lung cancer.
Subtitle
Hypofractionated proton beam therapy for centrally located lung cancer.
Proto therapy Time
May 2019
Executive summary
This study from Japan reported outcomes of 39 patients who received hypofractionated PBT for centrally located cT1-2N0M0. Twenty-four patients (62%) were treated with 80 Gy (RBE) in 20 fractions, whereas eight (21%) were treated with 66 Gy (RBE) in 10 fractions. The 2-year progression-free survival (PFS) and overall survival (OS) rates were 86 and 100% for T1 disease and 56 and 94% for T2 disease.
Dyspnoea of grade 3 was noted in one patient (3%), and pneumonitis of grade 2 was noted in four patients (10%). The authors concluded that hypofractionated PBT may be a very safe and effective treatment option for centrally located early lung cancer.
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