This study evaluated the health outcomes of 94 children with craniopharyngioma treated by protons. Body mass index, physical function and cardiopulmonary fitness was tested prior to proton therapy and annually for 5 years. This study found that BMI and knee extension strength had the largest proportion of participants impaired at both 2 and 5 years (53.2% and 62.3%, respectively). Resting heart rate had the highest proportion of participants not impaired at 2 years but became impaired at 5 years (26.6%).