Using Excess Absolute Risk (EAR) models, this study compared the risk of secondary cancer for Hodgkin lymphoma survivors after either IMRT or PBT radiation treatment. Organ-specific parameters were generated to model their uncertainties which the total EAR were around 13%, decreasing to around 2-5% for relative EAR comparisons.

This study found that IMPT decreased the average risk by 40% compared to the IMRT plan, 28% compared to the Volumetric Modulated Arc Therapy plan whereas the 3D Conformal Radiation Therapy plan is equivalent within the uncertainty.