Executive summary

Grade 4 lymphopenia (G4L) during radiation therapy (RT) is associated with higher rates of distant metastasis and decreased overall survival. 79 patients received XRT (27% 3-dimensional chemo-RT and 73% intensity modulated RT) and 65 received PRT (100% pencil-beam scanning) were evaluated.

The study reported that G4L was significantly higher in patients who received XRT versus those who received PRT (56% vs 22%; P < .01).

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