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Concurrent chemoradiotherapy using proton beams can reduce cardiopulmonary morbidity in esophageal cancer patients: a systematic review.

September and October 2023
Executive summary

To examine the superiority of PBT to photon-based RT in treating esophageal cancer patients, this systematic review included 23 original studies (1 randomized control study, 2 propensity matched analyses, and 20 cohort studies) for qualitative analysis. Overall survival and progression-free survival were better after PBT than after photon-based RT, but the difference was significant in only one of seven studies. The rate of grade 3 cardiopulmonary toxicities was lower after PBT (0-13%) than after photon-based RT (7.1-30.3%). Three of four reports evaluating the absolute lymphocyte counts (ALC) showed a significantly higher ALC after PBT than after photon-based RT.

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