This article presents the FLASH results of UPenn. An image-guided small animal proton research system was developed to enable in vivo investigations of radiobiological effects of proton beams, comparative studies between proton and x-ray beams, and investigations into novel proton treatment methods. The overall conclusion was that to aid pre-clinical research, integrated x-ray/proton systems can be developed at therapy clinics rather than relying on stand alone, expensive, dedicated facilities.