Subtitle
FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response
Subtitle
FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response
Proto therapy Time
September 2021
Executive summary
A study by the UPenn group reported that FLASH proton radiotherapy (F-PRT) of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton therapy (S-PRT) of the same dose.
RNAseq analyses of murine skin and bone revealed pathways upregulated by S-PRT yet unaltered by F-PRT. F-PRT reduced skin injury, stem cell depletion, and inflammation, mitigated late effects including lymphedema, and decreased histopathologically detected myofiber atrophy, bone resorption, hair follicle atrophy, and epidermal hyperplasia. F-PRT was equipotent to S-PRT in control of two murine sarcoma models.
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