Subtitle
Hypofractionated Radiation Therapy for Unresectable/Locally Recurrent Intrahepatic Cholangiocarcinoma.
Subtitle
Hypofractionated Radiation Therapy for Unresectable/Locally Recurrent Intrahepatic Cholangiocarcinoma.
Proto therapy Time
December 2019
Executive summary
This study by MGH retrospectively analyzed 66 patients with unresectable intrahepatic cholangiocarcinoma (ICC) who were treated with hypofractionated proton (32 patients) or photon (34 patients) radiation therapy (HF-RT). Median RT dose was 58.05 Gy, all delivered in 15 daily fractions. The 2-year outcomes were 84% local control (LC) and 58% OS.
On multivariate analysis for OS, compared with photon RT, there was a trend towards improved survival with proton RT (HR 0.50; p = 0.05). This study concluded that HF-RT yields high rates of local control and is an effective modality to optimize biliary control for unresectable/locally recurrent ICC.
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