Executive summary

Published in the Red Journal, this study evaluated 123 patients with intracranial tumors treated with protons with neurocognitive assessment available at baseline and 3, 6 and 12 months after completion of radiation treatment. At 1-year follow-up, 89.4% of all patients remained stable in their overall cognitive functioning without clinically relevant deterioration in 2 or more tests. 8.1% presented with radiation-induced brain lesions and exhibited a higher percentage of overall cognitive deterioration without reaching statistical significance. There was no significant correlation of hippocampal doses and memory functioning.