This study evaluated outcome of PBT for chordomas and chondrosarcomas. 20 adult patients with nonmetastatic chordomas of the skull base (n = 10), sacrum (n = 5), and cervical spine (n = 3), and skull base chondrosarcomas (n = 2) were treated with median dose of 73.8 Gy(RBE) using PRT-only (n = 6) or combination PRT/IMRT (n = 14).

The 3-year local control and progression-free survival was 86% and 81%. There were no deaths. Two patients had acute grade 3 toxicity (both fatigue). One had late grade 3 toxicity (epistaxis and osteoradionecrosis). The authors concluded that the reported local control, survival, and toxicity were favorable following PRT.