Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone.
This study reported outcomes of 19 patients with locoregional recurrent breast cancer treated with PT. All patients had mastectomy without prior RT. Seventeen patients were treated with PT to the chest wall and comprehensive regional lymphatics (17/19, 90%). With a median follow-up time of 13.4 months, 90% of patients were alive with no LRR or distant recurrence. Acute AEs were dermatitis (63% grade 2, 11% grade 3), pain (21% grade 2, 5% grade 3), fatigue (11% grade 2), and neuropathy (5% grade 2). Late AEs included dermatitis (11% grade 2, 5% grade 3) and lymphedema (5% grade 3). The authors concluded that PT was well-tolerated in the salvage setting with excellent loco-regional control.