This study reviewed 483 patients with various types of head and neck cancer (HNC), and reported that the nasopharyngeal carcinoma (NPC) patients had a higher frequency of temporal lobe necrosis (TLN) compared to non PNC patients (5.6% vs. 0.4%, p < 0.01). The frequency of TLN was similar between patients receiving PBT and those receiving VMAT (PBT vs. VMAT: 4.7% vs. 6.3%, p = 0.76). The authors concluded that their study demonstrated that patients with NPC were susceptible to TLN during the early period after RT. In addition, PBT may be associated with an equivalent risk of TLN when compared with VMAT in patients with NPC or other HNCs.