Subtitle
Toxicity and Survival After Intensity-Modulated Proton Therapy Versus Passive Scattering Proton Therapy for NSCLC.
Subtitle
Toxicity and Survival After Intensity-Modulated Proton Therapy Versus Passive Scattering Proton Therapy for NSCLC.
Proto therapy Time
October 2020
Executive summary
This MD Anderson study compared toxicity profiles and clinical outcomes after IMPT versus PSPT for 139 patients with locally advanced NSCLC. Compared to the PSPT group (n=86, 62%), the IMPT cohort (n=53, 38%) had lower rates of grade 3 or higher pulmonary (17% versus 2%, p = 0.005) and cardiac (11% versus 0%, p = 0.01) toxicities.
Six patients (7%) with PSPT and zero patients (0%) with IMPT experienced grade 4 or 5 toxicity. There was also a trend towards a longer median overall survival in the IMPT group (23.9 mo versus 36.2 mo, p = 0.09).
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