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A Systematic Review of Proton Therapy for the Management of Nasopharyngeal Cancer

08/06/2021
/ Publications
/
Nasopharynx
Oncology
PBT
IMRT
Head and neck
Mucositis
Overall Survival

This review examined 9 original studies and found that the oncologic outcomes of PBT were similar to IMRT with 2-year local and regional progression-free...

Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer

08/06/2021
/ Publications
/
Oropharyngeal Cancer
IMPT
IMRT
Head and neck
Chemotherapy

This study used clinicopathologic factors to match 25 patients with OPC who received IMPT and 25 patients with OPC treated with IMRT. Process maps were created...

PTCOG Head and Neck Subcommittee Consensus Guidelines on Particle Therapy for the Management of Head and Neck Tumors

08/06/2021
/ Publications
/
Head and neck
Particle Therapy
Nasopharynx
Sinonasal
Oropharyngeal Cancer
Reirradiation
IMRT
Phase III
Clinical Trial

This guideline reviews examined proton therapy for nasopharynx, reirradiation, sinonasal, postoperative and oropharynx and made recommendations. Proton therapy...

Clinical Outcomes of Pencil Beam Scanning Proton Therapy in Locally Advanced Non-Small Cell Lung Cancer: Propensity Score Analysis

08/07/2021
/ Publications
/
NSCLC
Clinical Outcomes
Thoracic
Chemotherapy
IMRT

This study retrospectively reviewed 219 patients with stage III NSCLC who received definitive concurrent chemoradiotherapy. 25 patients (11.4%) underwent PBSPT...

Establishing cost-effective allocation of proton therapy for patients with mediastinal Hodgkin lymphoma

08/08/2021
/ Publications
/
Hodgkin lymphoma
Dosimetry
IMRT
non-Hodgkin lymphoma

A health-economic study by the Jacksonville group. This study utilized (1) patient-level dosimetric information for a cost-effectiveness analysis using a Markov...

Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer.

03/03/2020
/ Publications
/
Gastrointestinal
Esophagus
IMRT
IMPT
PBT
Passive scattering

Published in JCO (Journal of Clinical Oncology), this randomized trial compared total toxicity burden (TTB) and progression-free survival (PFS) between PBT and...

Scanning Beam Proton Therapy (SPT) Versus Photon IMRT for Stage III Lung Cancer: Comparison of Dosimetry, Toxicity, and Outcomes.

05/03/2020
/ Publications
/
Thoracic
Phase III
IMRT
Lung
Esophagus

This study reviewed dosimetric data and clinical outcomes of 64 stage III lung cancer patients treated with SPT (34) + IMRT (30). Mean dose to lung, heart, and...

Comparative Analysis of 5-Year Clinical Outcomes and Patterns of Failure of Proton Beam Therapy (PBT) versus Intensity-Modulated Radiotherapy (IMRT) for Prostate Cancer in the Postoperative Setting

10/11/2020
/ Publications
/
Prostate
Genitourinary
PBT
IMRT

This case-matched study analyzed 260 prostate cancer patients including 65 treated with PBT and 195 IMRT. At a median follow-up of 59 months, biochemical...

Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.

10/10/2020
/ Publications
/
IMRT
Secondary cancer risk
Esophagus
Lymphoma
Lung
Breast

This study estimated secondary cancer risks for 23 mediastinal lymphoma patients treated with PBT in comparison with helical photon IMRT re-plans. PBT was...

Intensity-modulated proton therapy for oropharyngeal cancer reduces rates of late xerostomia.

05/04/2021
/ Publications
/
Head and neck
IMPT
IMRT
Oropharyngeal Cancer

This MD Anderson study published in the Green Journal retrospectively compares patients with oropharyngeal cancer (OPC) who received IMRT (n = 429) and IMPT (n...