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Hypofractionated Proton Therapy in Early Prostate Cancer: Results of a Phase I/II Trial at Loma Linda University.
A cohort of 146 patients with low-risk prostate cancer were treated to 60 Gy (cobalt Gy equivalent) of proton therapy (20 fractions of 3.0 Gy per fraction) in 4...
High-dose conformal proton therapy for clinical perineural invasion in cutaneous head and neck cancer.
Perineural invasion (PNI) is an uncommon (<5%) which refers to tumor cell invasion extensive enough to cause clinically detectable deficits of the involved...
Extreme hypofractionated proton radiotherapy for prostate cancer using pencil beam scanning: Dosimetry, acute toxicity and preliminary results.
A study by the research group in Prague. Two hundred patients with early-stage prostate cancer were treated with IMPT on extreme hypofractionated schedule (36...
Initial toxicity, QoL outcomes, and dosimetric impact in a randomized phase 3 trial of hypofractionated vs. standard fractionated PT for low-risk prostate cancer
A multi-center prospective phase 3 randomized trial aimed to identify differences in toxicity and quality-of-life outcomes between standard fractionation and...
Acute toxicity of image-guided hypofractionated proton therapy for localized prostate cancer.
A study reported toxicity of 526 localized prostate cancer patients treated with proton therapy and demonstrated the safety of HFPT for localized PCa patients...
Hypofractionation in Proton Therapy: radiobiological bases and clinical applications
The use of hypofractionated schedules in proton therapy is rapidly increasing. Their application has several advantages, including the reduction of overall...
A Pooled Toxicity Analysis of Moderately Hypofractionated Proton Beam Therapy and Intensity-Modulated Radiation Therapy in Early Stage Prostate Cancer Patients.
This multi-institutional study compared late toxicity profiles of a total of 1850 patients, including 1282 IMRT and 568 PBT. Overall toxicity rates were low...