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Brain volume loss after cranial irradiation: a controlled comparison study between photon vs proton radiotherapy for WHO grade 2-3 gliomas.

05/11/2024
/ Publications

This study from the MGH group analyzed brain volume change in two matched groups of patients with WHO grade 2-3 gliomas treated with either PRT (n = 17) or XRT...

Proton therapy for adult-type diffuse glioma: A systematic review.

05/11/2024
/ Publications

This review from the group of Caen, France included 12 primary studies for analysis, covering 570 patients with WHO grade 2-3 gliomas and 240 patients with...

Short-course hypofractionated proton beam therapy, incorporating 18F-DOPA PET and contrast-enhanced MRI targeting, for patients aged 65 years and older with newly diagnosed glioblastoma: a single-arm phase 2 trial.

27/02/2025
/ Publications

Published in the Lancet Oncology, this study from the Mayo Clinic group reported outcomes of 39 patients with WHO grade 4 glioblastoma treated with concurrent...

A Systematic Review on Re-irradiation with Charged Particle Beam Therapy in the Management of Locally Recurrent Skull Base and Head and Neck Tumors

08/06/2021
/ Publications
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Reirradiation
Toxicity

A review examined a total of 26 original studies (15 protons, 10 carbon ions, and 1 helium/neon studies) involving a total of 1,118 patients (437 with protons...

Outcomes following proton therapy for Ewing sarcoma of the cranium and skull base.

17/11/2019
/ Publications
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Secondary cancer

This study by the University of Florida, Jacksonville, reviewed 25 patients (≤21 years old) with nonmetastatic Ewing sarcoma of the cranium and skull base...

Clinical Outcomes of Recurrent Intracranial Meningiomas Treated with Proton Beam Reirradiation.

11/05/2019
/ Publications
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Reirradiation
Toxicity
Survival

This is a retrospective analysis of 16 patients who received PBRT reRT for recurrent meningiomas. The median PBRT dose was 60 Gy(RBE) and the median follow-up...

A Multi-Institutional Experience of Proton Beam Therapy for Sinonasal Tumors.

11/07/2019
/ Publications
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Toxicity
Reirradiation

Sixty-nine patients with sinonasal tumors underwent curative intent PBT including 42 patients received de novo irradiation and 27 received reirradiation. With...

Neurocognitive function and quality of life after proton beam therapy for brain tumour patients.

01/01/2020
/ Publications
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Quality of life

Published in the Green Journal, this multicenter study reported 62 brain tumor adult patients neurocognitive function after PBT. For two years of followup time...

Proton beam therapy utilization in adults with primary brain tumors in the United States.

03/03/2020
/ Publications

Based on the National Cancer Database, a total of 1,296 patients received PBT from 2004 and 2015 for treatment of their primary brain tumor. High-grade glioma...

Late contrast enhancing brain lesions in proton treated low-grade glioma patients: clinical evidence for increased periventricular sensitivity and variable RBE.

03/03/2020
/ Publications

Late radiation-induced contrast enhancing brain lesions (CEBL) on MR images after proton therapy of brain tumors have been observed to occur frequently in...