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Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT)

05/06/2024
/ Publications
/
Clinical Trial

Patients (n=440) were randomized to undergo IMRT(n=219) or IMPT (n=221) at 21 institutions. The median age was 61 years and HPV/p16 was positive in 95%. IC was...

An Interview with Dr. Steven Frank

17/07/2024
/ Webinar
/
Clinical Trial

Learn from Dr. Steven Frank as he discusses the results, challenges, and implications of the study "Phase III randomized trial of intensity-modulated proton...

Recent update of proton beam therapy for hepatocellular carcinoma: A systematic review and meta-analysis.

29/10/2024
/ Publications

This meta-analysis included 22 original studies involving 1858 HCC patients who received PBT to a total dose ranged from 55 GyE to 76 GyE. The median proportion...

Proton Beam Therapy for Treating Patients with Hepatocellular Carcinoma with Major Portal Vein Tumor Invasion: A Single Center Retrospective Study.

30/10/2024
/ Publications

This study from Japan reported favorable results of PBT in treatment of 116 patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT...

Hypofractionated Radiotherapy-Related Lymphopenia Is Associated With Worse Survival in Unresectable Intrahepatic Cholangiocarcinoma.

30/10/2024
/ Publications

This multicenter study led by the MGH group retrospectively analyzed 96 patients with unresectable intrahepatic cholangiocarcinoma (ICC) treated with...

Proton Beam Radiotherapy as a Curative Alternative to Radiofrequency Ablation for Newly Diagnosed Hepatocellular Carcinoma.

30/10/2024
/ Publications

This study by the group from Samsung Medial Center, Korea, compared the oncological outcomes of 323 patients with newly diagnosed hepatocellular carcinoma (HCC)...

Comparing 90-Day Postoperative Mortality After Neoadjuvant Proton-Based Versus Photon-Based Chemoradiotherapy for Esophageal Cancer.

30/10/2024
/ Publications

Ninety-day mortality (90DM) is an important measure of the postoperative (nononcologic) outcome as proxy of quality-of-care. This study by the MD Anderson group...

PTCOG Gastrointestinal Subcommittee Lower Gastrointestinal Tract Malignancies Consensus Statement.

30/10/2024
/ Publications

Lower gastrointestinal (LGI) tract malignancies arise from the rectum and anal canal. The PTCOG GI Subcommittee conducted a systematic literature review, and...

Optimizing GRID and Lattice Spatially Fractionated Radiation Therapy: Innovative Strategies for Radioresistant and Bulky Tumor Management.

30/10/2024
/ Publications

This review presents consensus guidelines for adoption and practice of GRID and Lattice RT, as well as detailed guidance for dosimetry and treatment planning of...