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Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT)

05/06/2024
/ Publications
/
Clinical Trial

Patients (n=440) were randomized to undergo IMRT(n=219) or IMPT (n=221) at 21 institutions. The median age was 61 years and HPV/p16 was positive in 95%. IC was...

An Interview with Dr. Steven Frank

17/07/2024
/ Webinar
/
Clinical Trial

Learn from Dr. Steven Frank as he discusses the results, challenges, and implications of the study "Phase III randomized trial of intensity-modulated proton...

Comparison of clinical outcome between surgical treatment and particle beam therapy for pelvic bone sarcomas: A retrospective multicenter study in Japan.

29/10/2024
/ Publications

This study from Japan reported outcomes of 116 patients with pelvic bone sarcoma treated by surgery (n=57) and particle beam (n=59, 55 carbon ion, 4 proton)...

Impact of proton versus photon adjuvant radiotherapy on overall survival in the management of skull base and spinal chordomas: a National Cancer Database analysis.

29/10/2024
/ Publications

This study reported treatment outcomes of proton or photon adjuvant therapy for chordomas of the skull base and spine. Data of 424 patients from the National...

Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024.

29/10/2024
/ Publications

This analysis from Japan based on 30 selected studies reported higher 5-year progression-free survival with particle beam therapy compared to photon RT for...

Hypofractionated proton and carbon ion beam radiotherapy for sacrococcygeal chordoma (ISAC): An open label, randomized, stratified, phase II trial

29/10/2024
/ Publications

. Published in the Green Journal, this study by the Heidelberg group reported treatment outcomes of 82 patients with inoperable or incompletely resected sacral...

Effectiveness and Safety of Carbon Ion Radiotherapy in Solid Tumors: A Systematic Review and Meta-Analysis.

30/10/2024
/ Publications

This systematic review and meta-analysis included 34 comparative studies and evaluated the effectiveness of carbon ion radiotherapy (CIRT) in patients with...

Quality-of-life evaluations in children and adolescents with Ewing sarcoma treated with pencil-beam-scanning proton therapy.

12/01/2023
/ Publications
/
Pencil Beam Scanning - PBS

This study investigated the QoL of patients with Ewing sarcoma treated with PBS-PT. A PEDQOL questionnaire evaluating eight different domains was filled by the...

Particle Therapy in Adult Patients with Pelvic Ewing Sarcoma-Tumor and Treatment Characteristics and Early Clinical Outcomes.

16/01/2023
/ Publications

This study reported early outcomes of 21 adult pelvic Ewing sarcoma treated with PT (n=18 primary disease) to a total dose of 45-60 GyRBE and with carbon ion (n...