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Top cancer treatments

Parallel explorations in LA-NSCLC: Chemoradiation dose-response optimisation considering immunotherapy and cardiac toxicity sparing.

29/10/2024
/ Publications

Published in the Green Journal, this study used dose-response models for predicting outcomes of chemoradiation (CRT) plus immune checkpoint blockade (ICB) for...

Sparing of the heart facilitates recovery from cardiopulmonary side effects after thoracic irradiation.

29/10/2024
/ Publications

Published in the Red Journal, this study from the Groningen group reported persistent reduction in cardiopulmonary function caused by radiation exposure of the...

A Pilot Trial of Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable Non-Small Cell Lung Cancer with Extended Durvalumab Therapy (PARTICLE-D).

29/10/2024
/ Publications

This phase I dose-escalation study by the group of Cleveland Medical Center, Ohio, reported severe treatment related toxicity. A total of 7 patients with stage...

Proton and carbon ion radiotherapy for operable early-stage lung cancer; a prospective nationwide registry.

30/10/2024
/ Publications

This registry study from Japan reported outcomes of 274 patients with operable lung cancer treated with proton (n=138, 50 %) and carbon ion (n=136, 50 %)...

Clinical Outcomes of Pencil Beam Scanning Proton Therapy in Locally Advanced Non-Small Cell Lung Cancer: Propensity Score Analysis

08/07/2021
/ Publications
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Chemotherapy
IMRT

This study retrospectively reviewed 219 patients with stage III NSCLC who received definitive concurrent chemoradiotherapy. 25 patients (11.4%) underwent PBSPT...

Treatment outcomes of passive scattering proton beam therapy for stage I non-small cell lung cancer

08/08/2021
/ Publications
/
Hypofractionation
Toxicity

A study by the NCC, Korea group. This study retrospectively analyzed 42 patients with stage I NSCLC treated with protos to an initial dose of 60 CGE in 4...

Incorporating NTCP into Randomized Trials of Proton Versus Photon Therapy.

11/03/2019
/ Publications

This study proposed and simulated a model-based methodology to incorporate heterogeneous treatment benefit of proton therapy versus photon therapy into...

Proton therapy for non-small cell lung cancer: the road ahead.

11/09/2019
/ Publications

This latest review article examined the up-to-date clinical data of PBT for both early stage and locally advanced stage NSCLC. In particular, this review...

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.

01/02/2020
/ Publications
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FLASH Therapy

Published in the Red Journal by the UPenn group, this paper reported the effect of FLASH proton versus standard dose rate PRT on tumors and normal tissues in...

A population-based assessment of proton beam therapy utilization in California.

01/02/2020
/ Publications

Based on data from California Cancer Registry, this study reported that of the 2,499,510 people with a cancer diagnosis during the study period, 578,632 (23%)...