Subtitle
The incidence of brainstem toxicity following high-dose conformal proton therapy for adult skull-base malignancies.
Subtitle
The incidence of brainstem toxicity following high-dose conformal proton therapy for adult skull-base malignancies.
Proto therapy Time
July 2022
Executive summary
This study by the Jacksonville group reported the incidence of brainstem toxicity after proton therapy. 163 patients with skull base chordoma or chondrosarcoma treated to a median total dose of 73.8 GyRBE were analyzed. With a median follow-up of 4 years, the 5-year cumulative incidence of grade ≥2 brainstem injury was 1.3%. There was one grade 2, one grade 3, and no grade 4 or 5 events, with all patients recovering function with medical management.
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