Subtitle
Surgery and proton radiation therapy for pediatric base of skull chordomas: Long-term clinical outcomes for 204 patients.
This study by the MGH group reported clinical outcomes of 204 pediatric patients with base of skull (BOS) chordomas treated by surgery and RT including forty-seven (23%) received protonRT, and 157 (77%) received comboRT. At a median follow-up of 10 years, 56 recurred. Median OS and PFS were 26 and 25 years, with 5-, 10-, and 20-year OS and PFS rates of 84% and 74%, 78% and 69%, and 64% and 64%, respectively. Side effects included 166 patients (80%) with mild/moderate acute toxicities, 24 (12%) patients with late toxicities, and 4 (2%) who developed secondary radiation-related malignancies.