A review article by MD Anderson examined the available outcome data of IMRT, SBRT and proton and carbon ion therapy for locally advanced pancreatic cancer, and pointed out that retrospective evidence suggests prolonged survival for patients who receive biological equivalent doses above 70 Gy (as compared to conventional 50 Gy in 25–28 fractions).

The advancements in treatment techniques and imaging modalities have enabled the effective and safe delivery of higher doses of radiation, and there is evidence that these higher doses may translate to better outcomes.