This study was to analyze survival and prognostic factors for intracranial ependymoma treated with postoperative radiation therapy in the 13 main French pediatric RT reference centers. Of the 202 patients analyzed, 62% received conformal RT verses 29% for intensity modulated RT and 8% for proton beam therap.

The study confirmed that tumor grade was the only prognostic factor for local relapse and disease free survival (DFS). Tumor grade, age, and extent of resection were independent prognostic factors for overall survival. DFS for intracranial ependymoma remains low, and new biological and imaging markers are needed to distinguish among different subtypes, adapt treatments, and improve survival.