Subtitle
Ultra-High Dose-Rate Proton FLASH Improves Tumor Control.
Subtitle
Ultra-High Dose-Rate Proton FLASH Improves Tumor Control.
Proto therapy Time
September 2023
Executive summary
This study reported that proton-FLASH (>60 Gy/s) was more effective in reducing tumor burden and decreasing tumor cell proliferation compared conventional proton irradiation (<0.05 Gy/s) based on a mouse model of NSCLC. Proton-FLASH was more efficient in increasing the infiltration of cytotoxic CD8+ T-lymphocytes inside the tumor while simultaneously reducing the percentage of immunosuppressive regulatory T-cells (Tregs) among T-lymphocytes.
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