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Top cancer treatments

Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial.

03/03/2020
/ Publications
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Model-based approach

Published in the Green Journal, this study was to assess whether a model-based approach applied retrospectively to a completed randomized controlled trial (RCT)...

Hypofractionated Proton Therapy With Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Phase I Trial From the University of Florida and Proton Collaborative Group.

03/04/2020
/ Publications
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Hypofractionation
Chemotherapy

Published in the Red Journal, this study reported the safety data from the first multicenter phase I trial investigating the use of hypofractionated proton...

NTCP Models for Severe Radiation Induced Dermatitis After IMRT or Proton Therapy for Thoracic Cancer Patients.

30/04/2020
/ Publications

Lyman-Kutcher-Burman normal tissue complication probability modeling for radiation-induced esophagitis in non-small cell lung cancer patients receiving proton...

Combining Immunotherapy with Radiation Therapy in Non-Small Cell Lung Cancer.

02/03/2020
/ Publications
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Immunotherapy

As immunotherapy, especially the immune checkpoint inhibitors have recently been demonstrated to improve survival in metastatic and locally advanced non-small...

Scanning Beam Proton Therapy (SPT) Versus Photon IMRT for Stage III Lung Cancer: Comparison of Dosimetry, Toxicity, and Outcomes.

05/03/2020
/ Publications
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IMRT

This study reviewed dosimetric data and clinical outcomes of 64 stage III lung cancer patients treated with SPT (34) + IMRT (30). Mean dose to lung, heart, and...

Proton therapy for thoracic malignancies: a review of oncologic outcomes

01/01/2021
/ Publications

This review examined PBT physical properties, treatment techniques including the recent advances in planning and delivery, and clinical outcomes for each of the...

Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.

10/10/2020
/ Publications
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IMRT
Secondary cancer

This study estimated secondary cancer risks for 23 mediastinal lymphoma patients treated with PBT in comparison with helical photon IMRT re-plans. PBT was...

Proton pencil beam scanning reduces secondary cancer risk in breast cancer patients with internal mammary chain involvement compared to photon radiotherapy.

01/10/2020
/ Publications
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Secondary cancer

This study compared tangential 3D-CRT and VMAT to PBS proton therapy in secondary cancer risk (SCR) for the lungs and for contralateral breast. PBS PT was...

Image-Guided Hypofractionated Proton Therapy in Early-Stage Non-Small Cell Lung Cancer: A Phase 2 Study.

10/11/2020
/ Publications
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Hypofractionation
Survival

22 patients with T1 to T2 N0M0 NSCLC received image-guided hypofractionated PBT to a total dose 48 GyRBE in 4 fractions for peripheral lesions and 60 GyRBE in...

Active-Scanned Protons and Carbon Ions in Cancer Treatment of Patients With Cardiac Implantable Electronic Devices: Experience of a Single Institution.

08/08/2019
/ Publications

A study by Heidelberg group looked into if ionizing radiation influenced the function of cardiac implantable electronic devices (CIED's) leading to malfunctions...