Proton and Carbon Ion Radiotherapy Decreased Severe Lymphopenia by Reducing Thoracic Vertebra and Aortic Dose in Non-small Cell Lung Cancer versus Intensity Modulated Radiotherapy.
Published in the Red Journal, this study reported lymphopenia differences between IMRT and proton/carbon ion (PCIRT) for NSCLC. With data of 343 patients, this study reported that the PCIRT group was less likely to develop severe lymphopenia (SRL) (p <0.001). Compared with non-SRL group, SRL group showed significant association with poorer OS, with median survival time of 29.2 vs. 15.0 months (p = 0.046). Thoracic vertebra V5 (p =0.002) and aorta V5 (p =0.026) were identified as independent risk predictors of SRL after adding dosimetric parameters to the regression model