Subtitle
Proton beam therapy for mediastinal Hodgkin lymphoma: A prospective study of clinical efficacy and safety.
Published in the Green Journal, this study by the group of Proton Therapy Center Czech, reported outcomes of 162 patients with mediastinal Hodgkin lymphoma treated with PBS-PT. With a median follow-up of 59.1 months, the disease-free survival, overall survival and local control rates were 95.1 %, 98.8 % and 98.8 % at 5-year, respectively. The most common acute toxicity included 10% grade 2 pharyngeal mucositis and 3% dermatitis. Late toxicity included 23% grade 2 hypothyroidism and 2% grade 2 cardiotoxicities, with no grade 3 and above late adverse effects. The authors concluded that PBT-PBS demonstrated excellent therapeutic outcomes, at least comparable, or even better than those observed in photon-based RT studies.