Executive summary

Published in the Green Journal, this study by the group of Proton Therapy Center Czech, reported outcomes of 162 patients with mediastinal Hodgkin lymphoma treated with PBS-PT. With a median follow-up of 59.1 months, the disease-free survival, overall survival and local control rates were 95.1 %, 98.8 % and 98.8 % at 5-year, respectively. The most common acute toxicity included 10% grade 2 pharyngeal mucositis and 3% dermatitis. Late toxicity included 23% grade 2 hypothyroidism and 2% grade 2 cardiotoxicities, with no grade 3 and above late adverse effects. The authors concluded that PBT-PBS demonstrated excellent therapeutic outcomes, at least comparable, or even better than those observed in photon-based RT studies.

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